Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
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منابع مشابه
Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
The hormonal factor(s) implicated as transmitters of signals from the gut to pancreatic -cells is referred to as incretin, and gastric inhibitory polypeptide (GIP) is identified as one of the incretins. GIP is a gastrointestinal peptide hormone of 42 amino acids that is released from duodenal endocrine K-cells after absorption of glucose or fat and exerts its effects by binding to its specific ...
متن کاملGastric inhibitory polypeptide (GIP).
As long ago as 1930, Kosaka and Lim proposed a humoral agent capable of inhibiting gastric acid secretion after a meal. They coined the term enterogastrone. Using crude preparations of cholecystokinin-pancreozymin (CCK PZ) in dogs they were able to inhibit the acid secretion normally stimulated by a meat meal or histamine. They went on to experiment with duodenal extracts, prepared after the in...
متن کاملGastric inhibitory polypeptide--its metabolic effects in sheep.
In simple-stomached animals secretion of the gut hormone gastric inhibitory polypeptide (GIP) is stimulated by intestinal absorption of glucose [I] and fat [2]. By contrast, in ruminants absorption of fat, but not of glucose, elicits GIP secretion [3]. GIP augments glucose-stimulated insulin release [4] and has direct anabolic effects on adipose tissue in simple-stomached animals [5,6]. Less is...
متن کاملInteraction of fat-stimulated gastric inhibitory polypeptide on pancreatic alpha and beta cell function.
Gastric inhibitory polypeptide (GIP) is considered to be the principal mediator of the enteroinsular axis. A glucose-insulin clamp technique was used to study the effects of differing blood glucose levels on the insulinotropic and glucagonotropic actions of fat-stimulated GIP in seven healthy subjects, as well as the effect of physiologic hyperinsulinemia on GIP secretion. Blood glucose levels ...
متن کاملGastric inhibitory polypeptide links overnutrition to obesity.
Obesity and diabetes are two of the most prevalent health conditions in industrial nations. Recent studies suggest that a gut derived peptide, gastric inhibitory polypeptide (GIP), may be involved in the pathogenesis of type 2 diabetes and obesity induced by overnutrition. 2 The “thrifty genotype” hypothesis suggests that those who are prone to obesity have been favoured by natural selection in...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2006
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db06-s011